PMID

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Article Title

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Semisynthetic analogues of toxiferine I and their pharmacological properties ata7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.

The German University In Cairo

Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.

Universit£

Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.

University of W�Rzburg

First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.

University of Bonn

Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.

The University of Toledo

Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors.

University of Bonn

Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.

University of South Carolina

Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors.

University of WüRzburg

Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.

University of Bonn

Mapping property distributions of molecular surfaces: algorithm and evaluation of a novel 3D quantitative structure-activity relationship technique.

University of Wuerzburg

Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding.

University of W£Rzburg

Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.

University of South Carolina

Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates.

Columbia University

Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.

Taisho Pharmaceutical

Muscarinic mechanisms of antipsychotic atypicality.

Eli Lilly

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Janssen Research Foundation

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.

Janssen Research Foundation

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.

Abbott Laboratories

Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor.

Merck Sharp & Dohme Research Laboratories

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.

Abbott Laboratories

Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites.

Stanford University

Characterization of high affinity [3H]pirenzepine and (-)-[3H] quinuclidinyl benzilate binding to muscarinic cholinergic receptors in rabbit peripheral lung.

University of Arizona

Characterization of muscarinic receptors in human, guinea pig and rat lung.

UniversitÉ